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The Korean company made the surprise move of releasing a larger variant of its popular Galaxy S6 Edge rather than simply sticking with its Note line of phablets, which launched in 2011 and defined the new half phone, half tablet category.
Perhaps Apple's most daring move will be what Gurman describes as a cheaper (but larger) variant of the iPhone X which the company believes will be "a model for everyone".
The larger variant AC133-1 (NM_006017) was identified first and contains all exons [15].
The size of the CD44 molecule ranges from the standard 85 95 kD form (CD44s) to larger variant isoforms of 200 kD or more due to RNA splicing and post-translational modifications [18].
However, for simultaneous processing of larger variant sets, collection and examination of annotations from different data sources quickly becomes cumbersome.
Although the individual variants are PASSing, manual review of the pileup (Additional file 1) immediately shows these variants to be artifacts of the larger variant.
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In subsequent decades, scientists found a few larger variants, with 14, 18, and 22 carbon atoms.
The ZenFone 5 and ZenFone 5Z look like larger variants of the iPhone X and even include the much maligned notch at the top, but these devices are far from cheap knockoffs.
These variants included single nucleotide variants (SNVs), indels and block substitutions as well as larger variants classified as CNVs and SVs that were called in comparison to reference sequence (NCBI Build 37).
Therefore, only even larger variants of several megabases, microscopically detectable upon conventional karyotyping, might impair chromosome synapsis and meiosis.
Small variants are more likely to regulate gene transcript than larger variants (p = 2.04e-08) with no preference in terms of type of polymorphism.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com