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This may be explained at least in part by the accumulation of apoptotic cells in the hair bulbs following the larger TBI doses (Fig. 3C).
Aries et al. have found in their much larger TBI cohort that hypoperfusion was associated with mortality while hyperperfusion was correlated with severe disability.
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The Eurotherm3235Trial will recruit 1,800 patients in 41 months and will be one of the largest TBI studies to date.
8 Additionally, it has been acknowledged that the effectiveness of TBI care and rehabilitation on the prognosis in TBI are best explored in large TBI populations.
The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial.
The present study gives a real-life example of the benefit two approaches to ordinal outcome analysis in a large TBI trial (the CRASH trial).
Also, further studies with larger numbers of TBI patients who with either left, right, or bilateral hemispheric lesions are needed to discern the relative influences of these two variables.
A large percentage of TBI victims show signs of further deterioration following the event (Sauaia et al. 1995).
The aim of this study is to investigate whether the benefits of an ordinal analysis would be upheld on analysis of the largest trial in TBI ever, which did demonstrate a true (but negative) treatment effect.
As the Marshall Classification holds comparable prognostic value to age, GCS, pupillary reactivity, SAH etc. [ 4, 7] and trauma registries commonly do not have record of this classification, the translation of AIS codes to the Marshall System opens up the possibility for multivariate prognostic analysis of large series of TBI subjects saved in trauma registries.
The current study represents one of the largest cohorts of mild TBI patients in the civilian population.
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