Both the loss of function (KO and KOd) and gain of function (OE) gene sets have a similar range of statistical significance (−log[q-value] 0 – 30) but the effect size (percentage change) for the knockout (KO and KOd) and OE sets differ, with the OE set producing a larger range of effect sizes skewed towards larger positive effects.
Because the PCB105 sample has relatively high efficacy, its competitive effect on TCDD is only moderate; consequently, the TEF model, although imperfect, is a reasonable description of the experimental data over a large range of effect.
A large range of adverse effects related to RBCs storage have been reported in critically ill patients when RBC stored for 2 to 4 weeks are transfused.
There is undoubtedly a very large range of disturbing effects, and causation is most of the time difficult to establish because time between cancer initiation and its detection is usually long.
Citreoviridin (CIT, Figure 1), a toxic secondary metabolite produced by Penicillium citreoviride species [ 1], is a common contaminant of wide range of agriproducts and has a large range of toxic effects, and CIT has been associated with human health risks [ 2, 3].
It is a systemic oral treatment which is taken for 15-20 weeks and produces long-term remission of acne symptoms in about 2/3 of people, but comes with a large range of side effects including causing severe birth defects, and must be administered by a physician.
Given the relatively large range of the effect estimates of earlier European studies, this study aimed to evaluate the effects of an automatic emergency call system on accident consequences in Finland (ex-ante evaluation).
The effect of intraperitoneal XE991 was variable, ranging from no change to a large inhibitory effect (n = 6) (Fig. S1).
For a large range of human health effects, such as female reproductive disorders and hormonal cancers, there are no viable laboratory models.
Their article reviews the existing epidemiologic data on exposures to PM from woodsmoke combustion, including wildfires, and concludes that within a large range of uncertainty, the effect of wildfire PM seems to be consistent with the effects of similarly sized PM from other sources of urban PM on an equal-exposure basis.
