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Large progress has been made in single-gene disorders associated with ischaemic stroke.
In spite of this, the last two to three decades have seen a large progress in knowledge about the complex biology of migraine.
Since the first observation [1] of carbon nanocones (CNCs), large progress has been made on synthesis, characterization, and manipulation of CNCs and carbon nanodisks (CNDs) [2 6].
Large progress has been done in ion-beam optics with the introduction of "elemental" blocks, that allows optical matrices calculation within LISE++.
Coagulation tests for LAC as well as solid phase assays for aCL and aβ2GPI have methodological shortcomings, although for LAC large progress have been made in standardization.
Recent advances in materials and computing technologies have resulted in a large progress in the use of 3D printing for biomedical applications.
By introducing the pattern recognition method [64], a large progress has been made; however, there is still a big gap between the research and its real application [65, 66].
In the last two decades, large progress has been made in the areas of feature-normalization, speaker-independent and speaker-adaptive acoustic modeling, and robust estimation methods for statistical language models.
