Sentence examples for larger modifications from inspiring English sources
In order to optimise the activity of the lead compound Cmpd (S −130 (3), we started by exploring larger modifications of the aromatic part of the molecule (selected examples are included in Table 1).
The second protocol tested was based on that of Silberberg et al. [22] and entailed substantially larger modifications to the ACSF than ACSF1.
In addition, we cannot exclude an effect of search algorithms in terms of a possible inherent bias against peptides carrying larger modifications.
CRISPR/Cas9 editing can also be used for generating larger modifications (i.e., insertion of reporter genes or antibiotic resistance markers) by providing dsDNA donor repair templates carrying homology arms flanking the site of alteration.
Whereas a 3 T vs. 7 T comparison of a 2D-PDT2 only requires slightly different TR and TEs, comparison of 3D-FLAIR and 3D-DIR requires larger modifications such as the prevention of increased, and unwanted, T1-weighting at 7 T by using magnetization preparation [ 19, 21].
In conjunction with the mentioned theoretical considerations we therefore cannot exclude that an additional contribution to the observed differences in identification rates could be due to the fact that peptides carrying larger modifications might be inherently more difficult to identify by search engine algorithms.
The double bacterial layer gives rise, as expected, to a larger modification in the THz transient.
When scanning the modification indices, only truly large modification indices should be considered, and not those near the 4.0 boundary of statistical insignificance, because considering larger modification indices reduces the risk of capitalizing on purely random variations.
Such large modifications implied a phenomenal climatic change that was not accepted by the general scientific community.
Both multiple mutants display large modifications of stability and activity arising from synergic effects in comparison with single mutations.
The notion of hypersensitivity is illustrated: a weak geometrical modification, a defect in connexion angle, can under certain conditions lead to large modifications of the vibrational behaviour.
