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Interestingly, genome sequencing revealed that wzm wzt were part of a larger locus encompassing 22 genes predicted to be involved in polysaccharide biosynthesis.
We also wanted to investigate the RE1 within the context of a larger locus, URI, which spans from 116 401 bp to 117 996 bp of the HSV-1 genome (Fig. 1).
One larger locus of 5S rDNA was located interstitially in the short arm of chromosome 6 and the other, weaker locus was situated in the pericentric region of the long arm of the same chromosome.
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We, therefore, grouped multiple loci that exhibit a common pattern of CpG metabotype associations into larger loci groups.
The rate of 3-bp deletions, for example, was significantly larger than the NR divergence rate at dinucleotidic loci shorter than 5 bp, though identical to the NR divergence rate for larger loci (fig. 4).
Of the two novel genes, KRT31 lies within a large locus encoding multiple keratin genes, in which we also observe associations with blonde hair.
RLE today is the second largest locus of graduate research assistants at MIT. Annually, over 250 graduate and 60 undergraduate students play integral roles in the Laboratory's mission of discovery.
I witnessed the power of this firsthand when I was invited to travel last month to Fort Jackson, in Columbia, SC, the US Army's largest locus of Basic Combat Training.
These observations, together with the high spontaneous mutation rate of NF1 (which is consistent with a large locus), suggest that NF1LT represents the elusive NF1 gene.
The largest locus, NELoc-1, consisted of netB and 36 additional genes, including those predicted to encode two leukocidins, an internalin-like protein and a ricin-domain protein.
However, visualizing large locus ranges can cause some display delays due to accessing of large amounts of genomic data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com