While there has been a rapid increase in the number of ncRNA sequences deposited in various databases over the past decade, the biological functions of these ncRNAs are largely not well understood.
The aetiology of many kidney diseases is still largely not well understood.
How and why insect wings developed, however, is not well understood, largely due to the scarcity of appropriate fossils from the period of their development in the Lower Carboniferous.
The biochemistry of the sortase-catalysed transpeptidation reaction is becoming well understood, largely as a result of studies on the housekeeping class A sortase, SrtA [25], [31].
The factors that govern infection and progression to active disease are not well understood, largely because the tools needed to study these phenomena are limited.
The process of dominance is not well understood largely because it is not possible to trace the cellular changes that occur within a follicle in real time in order to relate the events preceding development to future outcomes, such as predicting whether an individual follicle will become dominant or subordinate.
Due to a large volume of work in SAMs, it has been largely assumed that their characteristics are well understood, among these, the so-called odd-even effect.
While previous studies revealed that SRPK1 phosphorylates RS1, regiospecific and temporal-specific control within the largely redundant RS domain is not well understood.
Although the proximate mechanisms involved in stressor initiation and resource enhancement of cancer are relatively well understood, the evolutionary underpinnings remain largely unexplored.
The biochemistry and kinetics of formaldehyde are well understood and extensively characterized, due largely to the fact that it is an endogenous compound found in all living organisms and plays a well-established role in normal metabolic processes.
