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The strengths of our study are its very large size, prospective design, and population based nature, allowing precise and largely unbiased estimation of the association between offspring BMI and a large range of causes of death.
Statistical analyses were performed on physiological aggregates (P-set) and on arsenite-induced aggregates (As-set) using a largely unbiased set of 1475 proteins (MS proteome) detected by large-scale proteome analysis by multidimensional LC-MS (Washburn et al., 2001) as background.
The main advantage of bibliometry compared to other methods is that it permits a largely unbiased view of a field of study, that other forms of literature reviews may bring (Garfield, 1979).
Recent studies use either "shotgun" or PCR directed sequencing to get largely unbiased samples of all genes from all the members of the sampled communities.
In other words, the 89 gametes represent a largely unbiased sample.
Simulations have shown that LDhat produces largely unbiased rate estimates of the fine-scale genetic map [19].
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The sensitivity and specificity in CGH analyses largely depend on the unbiased amplification and labeling of probe DNA, and the sensitivity and specificity should be high enough to detect one-copy changes in aneuploid cancer cells when accurate assessment of chromosomal instability is needed.
It has to be noticed that CR and MACYT could not be measured in a few cases (DOE items 14 and 28 for CR, 26 for MACYT) but that the amount of experimental data (40 and 41, respectively) remains nevertheless largely sufficient for an unbiased subsequent modeling.
On the other hand, the GWAS signals are functionally unbiased but have largely not been attributed to causal or functional variants in genes.
Keith Stanovich at the University of Toronto has spent the last decade building tests for rationality, and he has found that fair, unbiased decision-making is largely independent of IQ.
The molecular identification of genetic factors that influence developmental ethanol toxicity has been hindered largely by the difficulty of performing unbiased, forward genetic screens in vertebrate systems, and it is here that our model is most useful.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com