The system of safeguards that was put in place over the years to protect investors and employees from a catastrophic corporate implosion largely failed to detect or address the problems that felled the Enron Corporation, say regulators, investors, business executives and scholars.
This approach is largely used to detect the expression variations of proteins prepared from two or more samples.
Pre-existing MNV-specific Trm cells provided partial protection against chronic infection but largely ceased to detect virus within 72 hours of challenge, demonstrating rapid sequestration of viral replication away from T cells.
Separate experiments have demonstrated that V1 and V2 cells are largely unable to detect the global form of glass patterns.
The situation is even worse for negative data (non-interactions) because experimental validation largely aims to detect but not exclude interactions.
Majority of them are heavily centralized and offer sub-optimal speed of surveillance, largely inadequate to detect outbreaks in a timely manner [ 6, 7].
In general, yeast proteins are very easily identifiable in shotgun proteomics experiments if their corresponding mRNA is present at 9 molecules/cell (or higher) on average, and at around 1 molecule/cell mRNA, current high-throughput methods largely fail to detect proteins.
Years of pummeling by Congress have so weakened the Internal Revenue Service -- eroding its budget, staff and spirit -- that the agency has largely abandoned efforts to detect tax fraud among the rich and powerful, or even among ordinary taxpayers.
This includes a commercially available antibody raised against human LAMP2A that has high reactivity to mouse LAMP2A (and8528) and antibodyody raised against the 12 amino acid cytosolic tail of rat LAMP2A which is identical to mouse protein (GLKRHHTGYEQF), and has largely been demonstrated to detect mouse LAMP2A but not other LAMP2 isoforms (Cuervo & Dice, 1996; Cuervo & Dice, 2000b).
Nevertheless, given the fact that we examined only a small proportion of the cells present in any tissue, we are largely limited to detecting relationships between cells that are only separated by a few cell divisions.
