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The MM-GBSA (molecular mechanics Generalized Born surface area) [ 25] is regularly employed to obtain estimates of the free binding energy of large systems and these are largely reasonable [ 30- 32].
This calculation of likelihood was based on the simplified assumption that normalized expression values of a gene under different conditions were independent, which was a largely reasonable approximation if gene expression experiments were carried out independently.
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He has also learned to wield the power of his position while earning a reputation among his House colleagues as a largely fair and reasonable leader.
8 As explained using an unusually explicit and detailed model, 1 the most effective intervention technologies available today have largely delivered on reasonable expectations but their fundamental limitations persist because the biology of malaria parasites and vectors have not changed.
This study was undertaken to test this reasonable, albeit largely unproved, assumption in a large, longitudinal sample.
The court is largely viewed as moderate, reasonable, and business-friendly.
Unlike, say, the Oscars, where expensive awards campaigns can tilt voters in a film's direction, the Grammys appear largely impervious to influence, reasonable or otherwise.
Those near 3,000 travelling Eintracht fans who chanted their opprobrium well remembered one of the few bumps in Wolfsburg's – and De Bruyne's – road in a 2015 that has largely soared past any reasonable expectations.
Sallyann's mother breaks in to tell them that it doesn't really matter whom they choose — "All cats are gray at night," she says, by which she means (she is very much a woman of her time) that men are largely interchangeable, and "any reasonable couple can . . .
The possible answers for a requirement in a checklist are: S = Satisfied; LS = Largely Satisfied; RS = Reasonable Satisfied; PS = Precariously Satisfied; D = Dissatisfied; NE = It could not be evaluated.
Given that histone point mutations often have a modest effect in yeast, and that the effects of histone mutations in mammals are largely unknown, it seems reasonable to wonder if histone acetylation is the most important physiological function for CBP/p300.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com