Sentence examples for largely mediated through from inspiring English sources

These processes are thought to be largely mediated through excess production of proinflammatory and catabolic mediators.

Improvement in functioning among patients on lurasidone was largely mediated through a reduction in depression symptoms, but lurasidone also had a medium and statistically significant independent direct effect in improving functioning.

Our findings suggest that acetylcholine-induced relaxation is largely mediated through the NO-cGMP pathway, involving apamin plus ChTx-sensitive K+ and Kv channels, and Na+−K+-ATPase pump activation.

At one end of this sits an archetypal "perfect consumer" whose life is largely mediated through and dominated by what are know as extrinsic values, like financial success, prestige, authority, individualism and materialism.

Taken together, these data suggest that DHA-induced cell death is largely mediated through the formation of intracellular ROS.

Mechanistically, the cell death induced by DHA is largely mediated through increased production of ROS in cancer cells, which subsequently results in apoptotic cell death.

Both standardized z-score birth weight and preterm delivery are strongly associated with neonatal mortality, and the effect of maternal smoking appears largely mediated largely through reduced fetal growth and, to a smaller extent, through shortened gestation.

This activity was largely mediated by HMGB1 through TLR-2, as it was abrogated by glycyrrhizin, an HMGB1 inhibitor [26], and also by neutralizing anti-HMGB1 and anti-TLR2 antibodies, but not by antibodies blocking RAGE or TLR-4.

Inhibitory neurotransmission in the brain is largely mediated by γ-aminobutyric acid (GABA) acting through GABA type A receptors (GABAAR)s and GABA type B receptors (GABABR s.

Even Bostrom's marriage is largely mediated by technology.

"MUD" stands for Multi-User Dungeon, and these precursors to the MMORPGs were worlds largely mediated by text alone.