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In the case of low preference heritability, classical theories of sexual selection would largely lose their applicability.
The first PI-II reaction centre would largely lose activity due to the absence of the one (C1) or both pairs of cysteine residues (C1, C2) of the centre (Figure 2).
Furthermore, VAR2CSA appears to be a major target of the antibody mediated immune response in pregnant women [15], [20], and parasites in which var2csa is genetically disrupted largely lose the ability to bind to CSA [12], [17] and placental syncytiotrophoblast [21], suggesting it is the primary var gene responsible for placental sequestration.
For instance, H1-depleted larvae largely lose the pericentric H3K9 dimethyl mark and [ 13].
By excluding individuals with modestly elevated glucose or lipid levels, these case-control series largely lose their relevance for investigating predictive potential in clinical practice, where persons with such levels are part of the population.
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But after Patco, that weapon was largely lost.
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That explanation was largely lost in translation, however.
Mr. Badillo's point was largely lost in the furor.
This advice has been largely lost to history.
This pungency is largely lost in the film.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com