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Cancer mutation hotspots in protein kinases are largely localized within the P-loop, hinge region, and activation loop (Figure 6A, Table S1).
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Motifs of conservation largely localize within or near the yar transcription unit.
Immunocytochemical labeling of 5-HT2A receptors and confocal microscopy revealed that 5-HT2A receptors are largely localized on layer II/III pyramidal cell bodies and apical dendrites within AC.
Although it was difficult to detect reliable PLD4 expression in mouse brains using these conventional methods, PLD4 expression was detected within the red pulp of the mouse spleen and was largely localized in cells around the marginal zone (Fig. 6A).
Rural speech was largely localized, the more mainstream patterns attaining a wider regional usage.
While the wind trio remained largely localized, the voices, building ever more sustained lines (doubtless prolonged electronically), were distributed throughout the hall.
Confocal microscopy revealed that LCP NPs were largely localized in hepatocytes not Kupffer cells.
Before World War II and the advent of the industrial food system, this infrastructure was largely localized, but today it no longer exists.
Immunohistochemical staining revealed that both receptor types were largely localized to the dorsal horn.
The Sigma-1 receptor (S1R) largely localized to the endoplasmic reticulum (ER) serves as a pluripotent intracellular signaling molecule with diverse roles in the cell including ion channel modulation, stress signaling, and transcriptional regulation (reviewed in Su et al., 2016), however, the basic topology of this protein within a cell remains controversial.
These deviations are largely localized to the regions displaying the highest temperature factors.
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