Sentence examples for largely localized to from inspiring English sources

Although PDI-family proteins are largely localized to the endoplasmic reticulum, recent reports have described a cell surface localization and function of these enzymes [55] [57].

Intratumoral staining was largely localized to tumor cells at the periphery of the microtumor nodules surrounded by stroma and vessels (Figure 5).

The Sigma-1 receptor (S1R) largely localized to the endoplasmic reticulum (ER) serves as a pluripotent intracellular signaling molecule with diverse roles in the cell including ion channel modulation, stress signaling, and transcriptional regulation (reviewed in Su et al., 2016), however, the basic topology of this protein within a cell remains controversial.

These deviations are largely localized to the regions displaying the highest temperature factors.

Knockdown of endogenous PTK6 protein that is largely localized to the cytoplasm resulted in decreased PC3 cell proliferation.

Among the BAD isoforms [17], BADL largely localized to the cytosol while BADS was identified in both cytosolic and mitochondrial fractions.

First, we used COS-7 cells, because these cells constitutively express endogenous TAg, which largely localizes to the nucleus [16], [17].

Interestingly, these factors largely localize to different sites in the cell.

These spots largely localize to centromeric regions, detected by the CREST autoimmune serum (Fig S4A in Supporting Information).

We propose that the modulatory effects of the proximal domain on HERG gating are largely electrostatic, localized to the charged KIKER sequence.

In physiologic situations, their actions may largely be localized to infected tissues and operate mainly via autocrine and paracrine stimulation.