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Malnutrition in those early years can be largely irreversible and causes delays in growth as well as mental health problems".
But losing access to crucial foreign markets as a result of currency movements outside the country's control is largely irreversible.
Our findings also argue against the growing sense of pessimism that the recent decline in LFPR is largely irreversible.
Another is that some of the underlying problems related to humanity's impact on the environment are largely irreversible.
Stunting is largely irreversible after the age of two, and results in reduced lifelong immune capacity, retarded cognitive and emotional development, and poor physical health.
Undernutrition in the first 1,000 days of a person's life has lifelong and largely irreversible effects because it impairs physical and mental development.
"After the age of two years, stunting is largely irreversible, and has an impact on growth and development and cognitive function," says Carrie Morrison from the World Food Programme.
This report found that recent and rapid human-caused changes have produced a "substantial and largely irreversible loss" in the diversity of life on earth and that two-thirds of the world's ecosystem services were declining.
If the climate silence and inaction continues, it may well be the story of the millennium — see NOAA: Climate change "largely irreversible for 1000 years," with permanent Dust Bowls in Southwest and around the globe.
Open cut mining heavily affects landscapes and is largely irreversible.
This is an alarming situation, since child stunting is largely irreversible when it is caused by long-term insufficient nutrient intake and frequent infections.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com