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Significant physical alterations have seemed largely impossible until very recently.
I knew that a child would make life as a professional explorer largely impossible.
"For modern art museums, what they're doing would be largely impossible".
"I think what they're trying to accomplish is largely impossible," he said.
"For us to try and do this in the offline world would be largely impossible," Mr. DePrano said.
A small group of meteorite-hunters are keen to resume a hobby that has been largely impossible since the revolution.
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As if having a long and largely impossible-to-pronounce name weren't enough for HSP (as we shall call her), now she has unleashed a full barrel of easily-recyclable witticisms to be shot in her direction.
Even those who bought early enough to have a profit on their home find it to be largely nominal, impossible to realise without removing themselves or their children from the all-important property ladder.
That would be impossible, largely because most coastlines have already been altered by such things as dams, pollution and aquaculture.
"It is hard to know where this will go," said Lieven De Winter, a professor of politics at the Université Catholique de Louvain, though like many others he believes breaking up the country would be so complicated as to be impossible, largely because neither side would give up Brussels, the capital.
For PCR methods, guaranteeing a complete Pareto front is theoretically a mission impossible, largely because of the stochastic nature of the population-based algorithms employed (Konak et al. 2006).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com