Sentence examples for largely implicated from inspiring English sources
A potential candidate for a transmembrane protein partner of the 500-kDa complex is the low-density lipoprotein (LDL) receptor related protein (LRP1), which is a large scavenger receptor mediating endocytosis of various biological components and is largely implicated in cytoskeleton organization [ 7, 62, 63].
Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also been largely implicated in cardiovascular disorders.
But, in a study released earlier this year, a gene-hormone interaction that appears to be largely implicated was identified.
The plasminogen activation system is largely implicated in pathological angiogenic processes.
Gap junctions have also been shown to be largely implicated in the mediators- and endothelium-related relaxation [5], [30].
MMP-2 is largely implicated in promoting angiogenesis and tumor metastasis.
Ventral frontostriatal regions have largely been implicated both in motivating behaviour towards obtaining desired outcomes or rewards and, subsequently, in the hedonic impact of rewards once obtained.
SphK2 which is largely less implicated in the overall production of S1P than SphK1 did not show any particular modification of its expression in AD brains which is consistent with literature [ 47].
Dopaminergic mechanisms may be involved in the pathophysiology of posttraumatic stress disorder (PTSD), although the evidence for this is limited; serotonergic mechanisms are implicated largely by virtue of the modest efficacy of serotonergic drugs in the treatment of the disorder.
Although JNK has been implicated largely in stress-induced apoptosis it has been postulated that JNK exerts an anti-apoptotic activity in p53-deficient tumor cells [ 22].
Although, epigenetic processes have been increasingly implicated largely from rodent studies involving nutritional manipulation of the dam [ 13, 14] the molecular mechanisms underlying altered disease susceptibility are largely unknown.
