Sentence examples for largely impaired from inspiring English sources

In this respect, PEBP1 and Complexin III downregulation is associated with impaired cholinergic neurotransmission (PEBP1) and synaptic transmission deficits (Complexin III), the two mechanisms largely impaired in AD and in mild cognitive impairment.

Numerous studies have shown that individuals with schizophrenia are largely impaired on this domain of cognition.

However, loss of PARP1 largely impaired the recruitment of PARP2 (Fig. 4d), indicating that the recruitment of PARP2 is dependent on PARP1.

Such a storm, witnessed from a large vessel, would be an inspiring sight, but was doubly so in a small craft, especially where the natural buoyancy had been largely impaired by overloading.

However, the ability of the cells to undergo osteogenic differentiation was largely impaired by the addition of either inflammatory factors or the P2X7R antagonist (BBG), whereas the P2X7R agonist (BzATP) was able to rescue the inflammation-induced reduction in osteogenesis.

Thus, it might be that with PD duration and H-Y stage increased, dopamine level was markedly depleted and motor symptoms were remarkably aggravated as substantia nigra was largely impaired by Lewy bodies, which further precipitated gastrointestinal dysfunction and constipation deterioration.

When the air is supplied at floor level, installing additional return grilles at exterior walls slightly alleviates the local draft risk, but doing so largely impairs the energy saving capacity of the ventilation system.

Thus, it can be concluded that at least for the two enzymes tested here, fusions to IFP did not largely impair their enzymatic activity.

The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life expectancy.

However, since accurate chromosome quantification requires a fully condensed chromosome state, only actively dividing cells can be assessed, largely impairing the biological application range [ 14, 15, 19].

Up to now this technique has rarely been used for the investigation of speech production paradigms because artifacts related to overt speaking largely impair the sensitivity toward task-related activation.