Sentence examples for largely impair from inspiring English sources

Up to now this technique has rarely been used for the investigation of speech production paradigms because artifacts related to overt speaking largely impair the sensitivity toward task-related activation.

Thus, it can be concluded that at least for the two enzymes tested here, fusions to IFP did not largely impair their enzymatic activity.

In this respect, PEBP1 and Complexin III downregulation is associated with impaired cholinergic neurotransmission (PEBP1) and synaptic transmission deficits (Complexin III), the two mechanisms largely impaired in AD and in mild cognitive impairment.

Such a storm, witnessed from a large vessel, would be an inspiring sight, but was doubly so in a small craft, especially where the natural buoyancy had been largely impaired by overloading.

Numerous studies have shown that individuals with schizophrenia are largely impaired on this domain of cognition.

Finally, there is an increased activity of MAO-A, which leads to the accumulation of toxic levels of H2O2 [71], and a largely impaired mitochondrial function [72].

When the air is supplied at floor level, installing additional return grilles at exterior walls slightly alleviates the local draft risk, but doing so largely impairs the energy saving capacity of the ventilation system.

Although the residue alterations at positions 1512 1526 and at position 1530 had minor impact on toxin efficacy, the exchange of hydrophobic Ile at position 1529 in DmNav1 to the Lys present in rNav1.2 largely impaired the toxin-channel interaction.

Although insulinoma growth in Perk-deficient mice was largely impaired, beta-cell mass was increased sufficiently by T-antigen induction to rescue the hypoinsulinemia and diabetes in these mice.

This error-free repair appears to be locally balanced with a strand biased error-prone introduction of mutations at A T sites, which is largely impaired in the absence of MutSα complexes.

This idea is strongly supported by the observation that the I V curves become insensitive to holding potential when [Cl−]o is reduced by about tenfold (18 mM), a condition under which chloride redistribution is largely impaired and intracellular chloride concentration is very unlikely to undergo massive fluctuations in response to migrations of the membrane potential.