Despite these notions, the breadth and depth of T cell epitopes derived from clinically important microbial agents of human diseases largely remain ill defined.
Occupational burnout is becoming an increasingly serious problem in the workplace but unfortunately remains largely misunderstood and ill defined.
The alterations that allow progressive invasion into the dermis remain ill defined, largely due to the limited availability of primary tissues, their heterogeneous nature, the interindividual genetic variability of tissue specimens and derived cell lines, and the lack of suitable experimental models.
However, CMAs have been ill defined and poorly evaluated, largely due to the lack of measurement tools to assess mobilization processes and impact.
In the latest issue of The Environmental Forum, Hayes writes: "With the exception of one bright spot — Zinke's proposal to establish a common regional structure for all of the department's bureaus — it is difficult not to be disappointed in what remains a largely ill-defined plan to meet unclear goals".
To date, its molecular pathogenesis as well as the sequence of events leading to retinal degeneration remain largely ill-defined.
Indeed, early in Gab signalling research, the dramatic electrophoretic mobility shift displayed by these docking proteins upon growth factor or cytokine stimulation was attributed to phosphorylation events, although the sites and signalling pathways remained largely ill-defined until the recent advent of sensitive phospho-proteomics.
Thus, not surprisingly, the genetic contributions to stunting are largely ill-defined, although the biological pathways associated with the identified loci can serve to help direct preclinical and clinical studies designed to assess the effects of various known or hypothesized environmental factors on the pathogenesis of stunting in at-risk populations.
However, the molecular identity of the epithelial cells in the mammary primordia is still ill defined, and the degree of similarity to postnatal mammary epithelial cells remains largely unknown.
As a health threat, it was ill defined.
And their long-term risks are ill defined.
