The corresponding Kd of ∼7 µM at 37°C establishes that RNA18 is largely double-stranded under the initial conditions of the ribonuclease assays.
After the bridge amplification step, cluster molecules are largely double stranded.
The three predicted structures of sra56 (6S) are similar, 6S being folded as a largely double-stranded RNA with a single-stranded central bulge.
The parapineal is required for elaboration of left-sided character of dHb neurons, and parapineal-ablated fish show largely double-right-sided habenulae [ 5, 6, 11], in which both left and right nuclei are innervated by mitral cells [ 21].
The Green Revolution was accomplished largely by doubling the amount of irrigated land.
Between 2010 and 2012 seizures of older synthetic amphetamine-style drugs, mostly methamphetamine, or "crystal meth", doubled, largely because of demand in Africa, Asia and South America. In America and Britain where the authorities conduct regular surveys of drug-taking, cocaine use has fallen steeply since around 2008.
The only growth has been in truck farming as production of vegetables has doubled, largely for local market.
By 1994, that number had more than doubled, largely because of campaigns promoting mammograms as potentially lifesaving tools.
So far this year, cachaca exports, while still small, have more than doubled, largely as a result of efforts by a handful of the country's largest producers.
Since November last year, Chinese stocks had more than doubled, largely due to small retail investors - 'mum and dad' investors playing the stock market - using borrowed money.
