Sentence examples for largely deleterious from inspiring English sources

This is what we describe it as an extensive and largely deleterious pleiotropy.

Gaining intuition from these simple models, we then present more extensive phylodynamic simulations that incorporate the occurrence of both antigenic and non-antigenic (largely deleterious) mutations.

Assuming that nonsynonymous mutations are largely deleterious or neutral, a relaxed action of purifying selection or an increased number of effectively neutral mutations would lead to higher P n / P s values.

To determine whether spindly HA phylogenies, co-circulation of antigenic variants, and high annual attack rates indeed come out of a model that incorporates deleterious mutations, we implemented a phylodynamic model that simulates the occurrence of both non-antigenic (largely deleterious) mutations and antigenic mutations ('Materials and methods').

Nevertheless, the conditions for this phenomenon, including close linkage and largely recessive deleterious effects, are so restrictive that they were never met in our panmictic base populations at the MSD balance, where neutral genetic diversity was never larger than that expected in the neutral model and did not increase with associative overdominance.

Exchanging cellulose for the soluble fiber (readily undergo bacterial fermentation) inulin largely reversed the deleterious effects of the CDD on the intestine (Fig. 5, F I).

Pretreatment of rats with CFTRinh-172 largely prevented the deleterious effects of cisplatin on renal integrity, likely through a decrease in cisplatin-induced oxidative stress.

A small number of fit males can provide a copy of the genome that is largely free of deleterious mutations for the next generation.

Because insect herbivores are richer in both N and P than are autotrophs, stoichiometric studies have largely focused on the deleterious consequences of ingesting excess C in order to obtain sufficient N or P.

The methoxyflurane fluoride nephrotoxicity threshold was largely surpassed without apparent deleterious effect on renal volume regulation and detoxification.

The deleterious effect of largely absentee directors is a worldwide phenomenon, and I hope the pendulum will begin to swing back.