Taken together, these factors have largely confounded previous attempts to assess the direct or upstream metabolic effects of KAAs.
These issues have largely confounded the studies of citicoline.
The fact that the crude and adjusted results were virtually identical may indicate that our results are not largely confounded.
In the present design, negative CT and genetic dominance are largely confounded, consequently genetic dominance could only be detected when effects of CT were eliminated from the model.
Third, satisfying the distinction between negative CT and genetic dominance was difficult as these two effects were largely confounded in the present study design.
One may argue that the most complete model is more interesting to investigate genetic architecture and chromosomal/sub-chromosomal variance but as we have shown SNPs and pedigree are largely confounded and they explain about the same variance.
Our results suggest that the relationship observed in previous research between diabetes and endometrial cancer incidence may be largely confounded by body weight, although some modest independent elevated risk remains.
Our data indicate that the relationship between diabetes and endometrial cancer incidence may be largely confounded by body weight, but did not rule out completely some independent association between newly diagnosed diabetes and endometrial cancer.
The association between CRP and lung function is largely confounded by smoking, but these previous longitudinal studies have generally not had adequate statistical power to quantify differences of associations according to some relevant subgroups, such as in lifetime nonsmokers versus smokers.
Although initial findings suggested statistically significant differences in both DFS and OS with the addition of a taxane, perhaps most notably in the US Intergroup CALGB 9344 study [ 4], these early trials are largely confounded by the perceived suboptimal efficacy of the control treatments when compared with optimal anthracycline-containing regimens.
