Sentence examples for largely complicated from inspiring English sources

Assemblers based on the de Bruijn approach may be largely complicated by sequencing errors.

This endeavour is largely complicated by the lack of a common standard.

5 This was largely complicated by heterogeneity of study populations and treatment procedures as well as approaches having been used, all of which influenced the outcome.

In the last decades, the need for preventive strategies has driven multiple efforts to develop an effective vaccine, however the existence of more than 90 distinct pneumococcal serotypes has largely complicated the development and evaluation of anti-pneumococcal vaccines.

Detailed molecular analyses are largely complicated by the covalent linkage of C3b molecules to the target surface and the requirement of C3 convertases to generate high C3b densities [ 12].

The existence of more than 90 distinct serotypes (differing in their chemical compositions, potential immunogenicity and epidemiological impact on different population groups) has largely complicated the development and evaluation of anti-pneumococcal vaccines[ 4].

But in this case, comparing to the tunneling regime, a new specific feature largely complicates the calculations.

Although most studies included a clear description of the immigrant groups, this classification varied largely, complicating the comparability of studies.

The merging step may introduce errors into the middle of reads that will largely complicate the de Bruijn graph used in assembly and result in incorrect assembly results in S. parasanguinis FW213.

Further structural characterization of GPCRs has largely been complicated by problems with expression, purification, and preservation of activity in vitro.

Similarly, Marc Bain of Newsweek opined: "The latest film version of Star Trek is more brawn than brain, and it largely jettisons complicated ethical conundrums in favor of action sequences and special effects.