Sentence examples for largely cluster from inspiring English sources

Mutations within the gene encoding p62 are commonly found in patients with Paget's disease of bone and largely cluster within the C-terminal ubiquitin-associated (UBA) domain, impairing its ability to bind Ub, resulting in dysregulated NF-κB signalling.

27 of these were present in the truncated CifEc structure and these largely cluster at three locations: (1) the active site and surrounding region, (2) a region that may be important for maintaining structural integrity and (3) a region for which sequence/structural conservation was not immediately apparent from the CifEc structure [8].

Note that groups (a) - e) from Fig. 2 largely cluster together in this tree.

However, the samples do largely cluster into three lineage groups in the PCA as well as by an unsupervised hierarchical clustering (Fig. 2C).

The affected genes largely cluster into Gene Ontology (GO) families localized to the plasma membrane and involved in signal transduction, and cell-to-cell signalling.

Analysis by consensus clustering, which performs multiple cluster analyses of different subsets of the data, demonstrates that the groups identified by SigClust largely cluster stably together with increasing k (Fig.  2 and Additional file 10).

Until 2004, JPMorgan has been largely clustered around Park Avenue, long the toniest street in American high finance.

The 50 or so bank failures have been largely clustered in a few states, like Florida, Arizona and California, where the bursting housing bubble had the greatest impact.

Drawn from the 80s emotional hardcore of Rites Of Spring and Ian McKaye's pre-Fugazi outfit Embrace, the scene was largely clustered around a few bands from the US midwest.

Homeworks was established by the Department of Housing Preservation and Development in 1995 "to put back into productive use as housing distressed, and vacant residential buildings largely clustered in city neighborhoods that were devastated by real estate abandonment, arson and disinvestment in the 1970's and early 1980's," Carol Abrams, spokeswoman for the agency, said.

In its report, HUD noted that "even among its relatively small minority population, persons of black race and Hispanic ethnicity are largely clustered in two minority-impacted census tracts," blacks in the housing projects of Marin City and Hispanics in the canal zone of San Rafael.