Sentence examples for largely bound to from inspiring English sources

Accessibility values to activities are largely bound to the spatial distribution pattern of activities; most equitable for intentionally dispersed recreation site, and least for spatially clustered hospitals.

Although S1P in blood plasma may reach up to micromolar concentrations, it is largely bound to plasma [18] [20].

During pregnancy, circulating PAPP-A is largely bound to the proform of Major Basic Protein (ProMBP) [ 30], which also forms a covalent complex with angiotensinogen [ 31].

While these receptors can be stimulated by soluble ligands, it is clear that chemokines in vivo are largely bound to heparan sulfate (HS) components of proteoglycans on cell surfaces and within the extracellular matrix (1).

Lp-PLA2 is largely bound to LDL in the circulation, possibly through apolipoprotein B (apoB) 100 [ 21], and whether or not to adjust analytically for apoB and/or LDL in studies of Lp-PLA2 and cardiovascular outcomes is a matter for current scientific debate [ 3, 22].

We also show that at the first stage of the HE SCL/TAL1, FLI1 and C/EBPβ largely bind to different sites, but are already associated with the same genomic neighbourhood.

However, it is also possible that both germline and somatic male-biased genes are not bound by the DCC in cell culture simply because they are not expressed in the particular cells in culture, as the DCC, once it has localized to the X chromosome, largely binds to expressed genes (Alekseyenko et al. 2006).

Chemical shift and transferred NOE data indicate that aS becomes slightly more helical but remains largely disordered when bound to CR. Results indicate that inhibition of fibril formation does not result from binding of CR to free aS and, therefore, must result from interaction of aS fibrils or protofibrils with CR micelles.

Examination of the Cryo-EM structure [ 28] indicates that this insert and the DPB2-binding subdomain (Zn fingers) are, largely, structured and bound to each other; furthermore, the presence of this insert places the DPB2-binding area spatially apart from the N-terminal, catalytic Exo-Pol module.

What all this shows, if more evidence was needed, is that an anti-piracy strategy based largely on enforcement is bound to fail.

Rosin's view was that the attitudes were largely irrelevant: they were bound to change, she said, and they "reflected more a lingering attachment to a certain ideal" — the way we in America pay lip service to traditional family values — than "a measure of how we want to live and definitely not of how we do live".