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The eye irritation potential of chemicals has largely been evaluated using the Draize rabbit-eye test for a very long time.
Fetal arousal tests such as vibroacoustic stimulation have largely been evaluated in high-income countries.
Mechanistic data to support health claims is often generated using rodent models, and the influence of prebiotic supplementation has largely been evaluated using male rodents.
Whilst the molecular mechanisms underlying cellular responses to thermal stress have been characterised in a number of model species [ 7– 11], the responses of marine species have largely been evaluated using a limited number of evolutionary conserved stress-responsive genes.
Variations in R2* have largely been evaluated in xenograft and human models using inhaled carbogen (95% oxygen (O2), 5% carbon dioxide (CO2)) to intensify the otherwise small changes in signal intensity: the CO2 induces vasodilation and the O2 tension is high with 95% O2 so that subtracted images with and without carbogen reveal regions of hypoxia where signal change is greatest.
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Denison's concerns here are partly related to the concept I mentioned earlier, namely that the 'easy' adaptations would largely already have been evaluated by natural selection over millions of years.
If during the Middle Ages the craft of musical composition had been evaluated largely in terms of its strict adherence to established rules, instinctiveness and spontaneity had remained suspect well into the Italian Renaissance.
Transitional care for older people has been evaluated largely in terms of re-hospitalization rates, thereby capturing specific dimensions of quality such as effectiveness, efficiency for inpatient providers, and risk and safety [ 27, 30].
By contrast, New Zealand's model of decriminalised prostitution was advanced by sex workers, and has since been evaluated with their participation (and largely to their satisfaction).
Q: Has this been evaluated?
As is the case with microphones, loudspeakers are evaluated largely on their frequency linearity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com