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The equivalent region in Ube2W is largely basic in character, which would likely exclude a positively charged lysine side chain from approaching the active site, but would accommodate a neutral N-terminal amino group.
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In response, the study committee, headed by George Paulikas, a retired executive of the space technology firm The Aerospace Corporation, ranks largely basic-science objectives.
Mr. McMillan's effort to remake Sara Lee largely reflects basic changes in the food industry.
Indeed, sarcopenia is an example of a major geriatric problem that has been studied largely in isolation in the basic and clinical aging communities, but is most effectively addressed with interdisciplinary, translational assessments of structure-function [ 51].
The first steps in this process are carried out largely by basic scientists and physicians working in a variety of research institutions and universities.
10 The prevailing hypothesis, based largely in the basic neuroscience literature, is that chronic smoking increases a person's susceptibility to anxiety and depression as a result of compensatory changes in neurocircuitry and/or neurophysiology caused by smoking.
A ballyhooed bill passed last summer was mostly a grab bag of subsidies and giveaways, largely useless in addressing basic problems.
With no timetable set for withdrawal and the daunting task of building (not REbuilding) a country that is mostly in the Stone Age, largely illiterate, lacking in basic infrastructure like roads and electricity, and wrecked by 30 years of continuous war, military experts are predicting that the total budget for the war in Afghanistan will eventually cost more than the Iraq war.
The State Department's annual human rights report, issued on Friday in Washington, said that the Turkish government "has long denied the Kurdish population, located largely in the southeast, basic political, cultural and linguistic rights".
Despite this tantalising evidence that innate immunity plays a critical role in the pathogenesis of polyarticular JRA, this aspect of the immune response has been largely overlooked in investigations into basic disease mechanisms.
In order to evaluate at low level detail the support provided by the different execution environments, we have developed JSBricks (Java Scientific Bricks), a suite of microbenchmarks that implement basic algorithms which are largely used in complex scientific applications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com