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We observed that blocking phosphorylation could largely abolish the interaction of β-TRCP with ZNRF3 (Fig. 3A).
MBNL1 is also sufficient to largely abolish DM1 foci in vivo.
Prompted by this observation, we also examined the TBC-like glutamine finger in VirA and found that substitution of Q280 by either a glutamate or an asparagine could also largely abolish VirA GAP activity by more than 90%.
Point mutants in the putative helix of the pore-forming regions have been described, which seem to largely abolish Ca2+ conductance and uncover dominant-negative effects with respect to NAADP-mediated Ca2+ signals (51, 52).
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Restrictions on accounts abroad, meanwhile, have been largely abolished.
These bodies would be largely abolished by Brown's proposals.
During the English Reformation the chantries were largely abolished.
Tariffs were slashed, exchange controls scrapped, the "licence raj" that strangled business in red tape largely abolished.
The name of the exam will not change, but marks for coursework will be largely abolished and a new grading system will be introduced.
During the next decade the measures benefiting the people were largely abolished, though the Gracchan land distributions, converted into private property, did temporarily strengthen the Roman citizen peasantry.
Brutal customs that were commonplace for millennia have been largely abolished: cannibalism, human sacrifice, heretic-burning, chattel slavery, punitive mutilation, sadistic executions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com