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In 1988, the World Health Assembly launched the Global Polio Eradication Initiative, which aimed to use large-scale vaccination with the oral vaccine to eradicate polio worldwide by the year 2000.
These results indicate that recombinant yeast-based oral fish vaccines have great potential for large-scale vaccination.
The principal idea behind the GPEI was to eliminate polio worldwide by the year 2000 by means of large-scale vaccination with the oral live attenuated polio vaccine (OPV) developed by Albert Sabin (1 ).
However, most were designed as injectable vaccines, which are not suitable for large-scale vaccination and cause too much stress to the fish.
The extent of serotype replacement under large-scale vaccination depends on the strength of competition between vaccine and nonvaccine strains.
Saha et al. report on assessment of the efficiency of public health managed large-scale vaccination clinics, referred to as points of dispensing (PODs), to administer pH1N1 vaccine in densely populated Los Angeles County, California, USA (3 ).
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In less wealthy regions, where the vaccines can have most impact, large scale vaccination efforts are still scarce [ 3, 4, 8].
In Europe, most countries (including Spain) have implemented strict national eradication programs based on initial large scale vaccination of pigs with attenuated glycoprotein E (gE -deleted vaccines.
The production of reference materials for quantifying pneumococcal antibody concentrations relies upon large scale vaccination.
We discuss evidence obtained from observations in vitro, in vivo in animal models and from clinical applications, including adjuvants used in large scale vaccination today.
This provides a significant benefit over other delivery platforms, especially where repeated administration or large scale vaccination is required.
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