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In addition, large-scale small RNA sequencing confirmed the occurrence of the expected 21-nt miR319e-GFP species and other 22- and 24-nt species that exhibited sequence relationships with the expected amiRNA.
Recent study using a large-scale small interfering RNA screen identified more than 250 host factors required for HIV-1 infection [46], [47].
Similarly, large-scale small interfering RNA (siRNA) and cDNA functional genetics screening strategies could be designed to identify host cell factors modulating L1 activity.
In a large-scale small interfering RNA (siRNA) screen, we found that knockdown of the tumor suppressors Folliculin (Flcn) and Tsc2 prevent ESC commitment.
Although the miRNA* strand is generally considered to have no functional role due to its low abundance, some miRNA* have been detected with high abundance during large-scale small RNA sequencing.
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We study the dynamics of a game-theoretic network formation model that yields large-scale small-world networks.
These characteristics not only allow the study of hepatology in 3D using inexpensive cell lines, but also permit large-scale small-molecule screening.
For a large-scale, small-molecule screen, we would thus recommend use of a two-concentration standard assay (10 μM/100 μM).
We caution that a primary large-scale, small-molecule screen carried out using the ChIn assay would not distinguish (1) a specific anti-inflammatory effect, (2) an inhibitory effect on general cell motility and (3) protection of hair cells from undergoing cell death, as all of these events would result in the same net effect: Recruitment of leukocytes to neuromasts would be altered.
Table 1 The space of visual learning analytics and open learner models Visualisation type For teachers (and other professional stakeholders) For students (and perhaps teachers, parents, peers) Activity, behaviour, performance score data Inferred learning information Large scale Small scale Learning analytics x x x Open learner models x x x.
At a slightly larger scale, small disturbances of a competitive dominant can open space allowing good colonizers to coexist with dominant competitors via competition colonization tradeoff.
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