Large-scale deletions of statistical significance were observed at 1p/1q, 3p, 6p/6q, 8p, 9p/9q and 14q, and large-scale amplifications/duplications of statistical significance were observed at 5p/5q, 7p/7q, 8q and 20p/20q.
For one, every large-scale composition assumed artistic significance of a type previously accorded only a whole series of works, sometimes a composer's entire output.
As with all large-scale screens, the biological significance of this observation should be further confirmed, for example, by interrogating a larger panel of cell lines.
Hypermethylation in cancer vs. adjacent samples was seen at a significance level of p ≤ 0.001 for 12 of the 16 test regions in the large-scale study and at a significance level of p ≤ 0.01 for three of the seven regions not pursued beyond the pilot phase (Table 3).
The significance of large-scale WSNs has been emphasized by the emerging internet of things.
NB is characterized by non-random chromosomal abnormalities with diagnostic and prognostic significance, including large-scale chromosomal imbalances [ 10– 10].
Rather the pattern specificity of folds, their co-localization with cytoarchitecture, and their heritability together denote the biological significance of large-scale morphology.
Along with their expanding size, the value and significance of large-scale oncogenomics datasets will continue to rise in the coming years.
Recent studies in schizophrenia [ 39] and epilepsy [ 10] identified rare variants through whole-exome sequencing but failed to identify a single variant that reached study-wide significance, despite large-scale genotyping in follow-up cohorts.
Even when power is insufficient to achieve statistically independent genome-wide significance, recent large-scale studies using summary-level data have shown unexpectedly high rates of directional consistency across transethnic GWAS signals [ 29].
