First, large-scale reviews of hundreds of Phase I trials have indicated there is a relatively low risk of serious harm and some prospect of clinical benefit that can be meaningful to patients.
There have been two large-scale reviews comparing administrative to self-report data [ 6, 7].
Two large-scale reviews attempted to assess the effects on LTLS/CTLS and AKI/need for RRT; these were a Cochrane database systematic review of the pediatric literature in 2014 17 and a systematic review by Lopez-Olivo et al of the adult literature in 2013.
The CIPD is now calling on the Conservatives to conduct a large-scale review into how the UK can ensure crucial public investment achieves the best value for all learners, and also recommends the Government ensures its productivity plan includes a specific focus on creating more high-skilled jobs.
However, a large-scale review gathering systematic data to find academic concerns about the TGP is missing.
Similarly, the Ted Stevens case, fought aggressively by some of the best criminal attorneys in the world, uncovered serious problems that sparked a large-scale review of prosecutorial practices throughout the country.
The 1976 Church Committee Report, the first and only large-scale review of America's internal spy networks, found that between 1953 and 1973 nearly a quarter of a million first-class letters were opened and photographed in the United States by the CIA.
This is in accord with a large-scale review which showed that all personality disorders evinced an increase in the risk for violent crimes [ 41].
In a large-scale review of factors affecting adherence to treatment for LTBI [ 6], perceived severity of TB, perceived susceptibility to TB, and perceived accuracy of LTBI diagnosis were all identified as correlates of LTBI adherence.
Large scale reviews of the antibacterial research at the pharmaceutical companies GSK [3], and, more recently, Astra Zeneca [4], have highlighted the challenges involved.
Treatments from large scale reviews that report positive effects most strongly include: allergen immunotherapy (57 trials) [ 76], beclomethasone (60 trials) [ 82], budesonide (43 trials) [ 84], fluticasone (75 trials) [ 96], ICS compared with sodium cromoglycate (25 trials) [ 88], LABA (67 trials) [ 62], and LABA vs. SABA (31 trials) [ 75].
