"large-scale regulation" is a correct and usable phrase in written English.
It refers to the implementation and enforcement of laws and rules on a wider, nationwide or international level, as opposed to smaller, local regulations. Example: The government has implemented large-scale regulation to control the emission of greenhouse gases and reduce their impact on the environment.
This raised the possibility of the chromatin structure being involved in large-scale regulation of transcription.
3: Chromosomal localization seems to be important in the large-scale regulation of mRNA transcripts in response to Aroclor 1254.
Here, we present a framework for studying a gene regulatory network and the large-scale regulation of transcription on the level of chromatin structure.
However, mapping the Aroclor 1254-induced transcriptome back onto the genome was useful to get insight into the large-scale regulation of transcription.
We recently mapped the Aroclor 1254-regulated transcriptome back onto the genome in order to get insight into the large-scale regulation of transcription [ 8].
Here, we found that genes regulated by Aroclor 1254, are much closer located to each other than genes distributed randomly all over the genome, which raises the possibility of chromatin structure being involved in the large-scale regulation of transcription.
The results presented here provide the first evidence of large scale regulation of c-Myb activity and specificity in cells that are in different growth phases, suggesting that c-Myb is regulated largely by protein-protein interactions that help guide it to different target genes in different types of cells.
The Sherman Antitrust Act, and others before it, initiated large-scale government regulation.
Here, we review the impact of recent technological advances on our understanding of large-scale gene regulation in vertebrates, by focusing on paradigmatic gene loci.
Alternatively, a large-scale gene regulation model can be constructed based on stoichiometry without a large number of fitted parameters.
The predominant direct effect of a miRNA would be through translational inhibition, whereas the predominant indirect effect would affect protein levels through large-scale transcriptional regulation.
