Furthermore, generation of testable hypotheses for defining points of pharmacological intervention in AD are complicated by the large scale occurrence of older individuals dying with no cognitive impairment despite having a high burden of AD pathology (plaques and tangles).
Using pseudo-presence data may lead to overpredictions in characterizing climatic suitability because large-scale "extent-of-occurrence" geographical ranges include some unsuitable areas and thus tend to exaggerate actual occurrence [45] [47].
The increasing availability of time series microbial community data from metagenomics and other molecular biological studies has enabled the analysis of large-scale microbial co-occurrence and association networks.
While these efforts will affect the evolution and spread of resistance, mounting evidence suggests that these changes alone will not lead to large-scale reductions in the occurrence of antimicrobial resistance14,15,16,17,18.
For this study we collected eight years (2006 2013) of data on Chongming Eco-island in China, analyzing the effects of large-scale agriculture on the occurrence of the rice leaf roller, Cnaphalocrocis medinalis Guenée, a dominant foliage feeder in rice ecosystems.
AquaMaps is a bioclimatic envelope model that combines existing point occurrence data with available expert knowledge on species occurrence in environmental and geographic space to generate large-scale predictions of the relative occurrence of marine species.
In this work, we localized the PPI of Arabidopsis thaliana from database STRING (http://string-db.org/) [ 24], which integrates and weights information from numerous sources, including conserved neighborhood, gene fusions, phylogenetic co-occurrence, co-expression, database imports(e.g. MINT, HPRD, BIND, DIP, BioGRID, KEGG and Reactome), large-scale experiments, literature co-occurrence [ 25].
CNDD can be investigated in several ways including manipulative seedling survival experiments (Reinhart et al. 2012; Fricke et al. 2014), large-scale assessments of co-occurrence patterns between juveniles and adults (e.g. Johnson et al. 2012), and fine-scale spatial analyses (e.g. Johnson et al. 2014).
In our study, we used the protein-protein interactions from the STRING database [ 50], which integrates and weighs information from numerous sources, including conserved neighborhood, gene fusions, phylogenetic co-occurrence, co-expression, database imports, large-scale experiments, and literature co-occurrence [ 51].
Consequently, these data are extremely useful to alert authorities about the occurrence of large-scale deforestation events, but do not capture small-scale deforestation.
