In addition, advances in sequencing technologies will allow large-scale interrogations of coding regions in the genome likely to detect rare variants of strong effect.
(If it did, the results could be dramatic: widespread police interrogations, large-scale detentions, fractured families, economic upheaval, and a fiercer backlash).
So far, large-scale T-cell repertoire analysis has been limited to interrogation of a single TCR subunit per sequencing run.
Large-scale screening in Drosophila cultured or primary cells facilitates rapid genome-scale interrogation of gene function.
67 The goal of this free and widely available online resource is to integrate a variety of large-scale datasets from eukaryotic pathogens and their hosts, and facilitate data interrogation in an easily accessible system.
It is beyond the scope of this manuscript or our lab to develop interactive data interrogation tools for these data as these efforts are often large-scale projects (e.g., iPlant is a $100M NSF Center, KBase is $100M DOE Center).
Although models always fail to capture the full complexity of immune responses, we posit that model building allows thorough, iterative interrogation of the sufficiency of molecular steps to account for large-scale functional properties (Kemp et al., 2007; Janes et al., 2008).
Multiplex SNP genotyping allows the simultaneous high-throughput interrogation of hundreds of thousands of loci with high measurement precision at a cost that enables large-scale studies.
Ah, large-scale ecclesiastical patronage.
