The discrepancy between divergence on fine scale and conservation on large scale indicates different forms of control of recombination rate on different scales.
Target site in exon 2 is shown below in larger scale, indicating the CRISPR AN19NGG target site.
Red rectangle in the large-scale map indicates the study area.
This large-scale response indicates that S. bayanus shows the canonical environmental stress response identified in S. cerevisiae (Gasch et al. 2000) and other yeasts (Gasch 2007).
The available evidence on rimonabant 20 mg/day from four large-scale RCTs indicates efficacy for up to 2 years on weight loss and across a range of cardiovascular and metabolic risk factors in obese and overweight patients, and in patients with diabetes and dyslipidemia (see the Evidence summary table on the opening page of this article).
The ICER for vaccination would have been more unfavorable if such expenditures had been included; however, the available evidence from large-scale studies indicates that PCV-7 was well tolerated and that the impact on cost and quality of life would be minimal.
Phylogeographic patterns in southern Australia indicate that major biotic responses to climatic change involve persistence and resilience rather than large-scale migration, indicating the importance of dynamic evolutionary processes and a mosaic of habitats in heterogeneous landscapes for species to persist though changing environmental conditions.
Estimates from a large-scale study indicated some astounding statistics: in response to incivility experiences, 48% of employees intentionally decreased their work effort, 47% intentionally decreased their time at work, and 38% intentionally decreased the level of quality in their work.
Experimental results in a large-scale network indicate that the proposed algorithm can quickly find the high-quality solutions with small relative gaps, demonstrating the effectiveness of the proposed approaches.
The rocks lack large-scale bedding, indicating weak traction processes.
However, this intuitive 'show them and they will adopt' model has yet to produce desired large-scale transformations, indicating that a more robust research-based model of change is needed (Fairweather [2008]; Seymour [2001]; Henderson et al. [2011]).
