Sentence examples for large-scale imbalances from inspiring English sources

The detected large-scale imbalances were either recurrent or appeared only once in our samples.

In order to exclude any effect of large-scale imbalances (such as trisomies or monosomies), the gene-centered CGH/expression correlations were computed in the relevant genomic regions only for tumors without the large-scale imbalances.

Genomic regions involved in large-scale imbalances such as trisomies or monosomies were analyzed separately by removing data from trisomic or monosomic tumors.

Species with heteromorphic sex chromosomes face the challenge of large-scale imbalance in gene dose.

The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes, and between sex chromosomes and autosomes.

Importantly, this report, together with a recent study of sex-biased expression in somatic tissue of chicken, demonstrates the first example of an organism with a lack of global dosage compensation, providing an unexpected case of a viable system with large-scale imbalance in gene expression between sexes.

In addition, we demonstrate that many of the recurrent large-scale chromosomal imbalances, including loss of 1p, 3p, 11q and 14q, along with gain of 1q and 17q, have also had a major impact upon miRNA expression.

In addition, we also determined that there was a highly significant correlation between miRNA expression levels and DNA copy number, indicating a role for large-scale genomic imbalances in the dysregulation of miRNA expression.

We conclude that there is widespread dysregulation of miRNA expression in neuroblastoma tumors caused by both over-expression of the MYCN transcription factor and by large-scale chromosomal imbalances.

Here, we expression profile 430 miRNA loci in 145 tumors that have also been characterized by high resolution aCGH, allowing identification of miRNAs which are associated with patient survival, differentially expressed in genetic subtypes, and that have been dysregulated by both over-expression of the MYCN transcription factor and large-scale chromosomal imbalances.

NB is characterized by non-random chromosomal abnormalities with diagnostic and prognostic significance, including large-scale chromosomal imbalances [ 10– 10].