Unfortunately, there is still lack of large scale hearing screening and surveillance programs in many developed and developing countries, including Brazil, even though some recent studies have demonstrated that the implementation of adult hearing screening might be a cost-effective way to reduce unmet need for hearing aids and improve quality of life among older adults [ 16, 27].
As such, a major impediment to progress in the discovery of risk loci for hearing in humans is the lack of control of the many environmental factors that affect hearing during the lifetime, and, to date, only a limited number of large-scale GWAS for hearing phenotypes have been undertaken in humans.
At a youth tournament in Ireland as a teenager, he was confronted for the first time with large-scale racism as he heard hateful chants from a group of Irish fans.
During the 1930s the orchestra presented rarely heard large-scale works from the past, including Berlioz's Grande Messe des morts and Grande symphonie funèbre et triomphale.
But then, Yonkers schools always seem to be one step away from financial disaster, and by now, many residents here have grown accustomed to hearing about large-scale layoffs that never come.
Thomas, who had well-placed friends, had heard that large-scale massacres of Tutsis were being prepared nationwide by the President's extremist entourage, and that lists of Hutu oppositionists had been drawn up for the first wave of killing.
Conversely, the success of global collaboration and data sharing, championed in human genetics by the Wellcome Trust, among others, is being replicated in other species: we heard about large-scale international collaborations in mice, cattle, Arabidopsis, maize and Drosophila.
Audiometry is the gold standard for evaluation of hearing loss, but large-scale use of the procedure involves operational difficulties.
"Large-scale manufacturers' voices are not being heard," she said.
But the local chief has heard rumours about large-scale land deals in other parts of the west African country – where estimates suggest nearly 20% of farmland has been snapped up by investors – and says he wants to be ready if and when companies come to his area.
Now, we've all heard of the large-scale, headline-grabbing mega acquisitions of WhatsApp, Nest, Beats, Oculus VR, and Waze.
