Mugsy does not require a reference sequence, can align mixtures of assembled draft and completed genome data, and is robust in identifying a rich complement of genetic variation including duplications, rearrangements, and large-scale gain and loss of sequence.
We isolated fezf2 from an in vivo large-scale gain-of-function screen aimed at identifying novel regulators of several signal transduction pathways during early Xenopus development (Zhang et al., 2013).
These diseases, which demonstrate large-scale gain or loss of chromosomes, are often associated with loss of DNA methylation at centromeric and/or pericentromeric loci (Gisselsson et al. 2005; Hansen et al. 1999; Lengauer et al. 1997; Wong et al. 2001).
H3.3 wild-type tumors showed large scale gains of chromosomes 2p and 7p as well as losses of chromosome 9p and 12q.
The electroporation vectors described in this article open the way to large scale gain-of-function screens by electroporation of small pools of cDNAs under control of a suitable driver, analogous to those successfully carried out in Xenopus and fish by the more tedious mRNA injection method.
In addition, other regions carrying recurrent large-scale CN gains and losses (arbitrarily defined as regions of >1500 kb) were identified at the 8q21.13, 17p12, 17p11.2, 22q13 and Xq25 chromosome segments (one in each chromosome).
In order to determine if large-scale genomic gains and losses might have widely impacted upon miRNA expression, we correlated gains and losses of genomic regions, as determined by aCGH on each tumor, with relative miRNA expression values.
But many economists are doubtful that the economy, while increasingly robust in many ways, will begin generating large-scale employment gains anytime soon.
Note that if multiple antenna elements are collocated at one RRU, then the corresponding large-scale channel gains are equal.
The large-scale fading gains of the uplink and downlink channels are equal and the small-scaling fading uplink channels are subject to i.i.d.i.d
The major benefit of this scenario is that we only need to employ one single parameter d to reflect user location, which determines the large-scale channel gains of desired and interfering channels.
