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The August 2001 version, the latest analyzed, was a "real improvement," the Decode scientists say, but still contained 104 large-scale errors, according to their recombination map.
"The risk is that some of the investigations now under way uncover criminal misconduct or large-scale errors that force foreclosures to be put on hold for an extended period of time," he said.
Corrections are not surprising in a draft that is continually being improved, but the presence of so many large-scale errors raises the question of whether the genome will really be finished by its target date next April, said Dr. Huntington F. Willard, a geneticist at Case Western Reserve University.
Through its detailed knowledge of Icelandic genomes, for example, Decode has discovered and been able to correct many large-scale errors in the human genome sequence produced by the public consortium of academic centers, Dr. Stefansson and colleagues report in the current issue of Nature Genetics.
As DNA sequencing technology accelerates, it is critical to ensure that high-fidelity sequence assemblies are obtained, and that large-scale errors be readily detected.
The validation and refinement finishing stage aims to correct errors in the assembled sequence - both single-base errors (such as mis-called bases due to sequencing errors) as well as large-scale errors (such as mis-assemblies due to repeats).
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In cases where an institutional investigation of large-scale error or misconduct is under way, Science may publish an Editorial Expression of Concern relating to the paper in question.
When the different acquisitions were mosaicked together, such large scale errors appear as blocks.
Hence, for real data, pedigree-based evaluation may actually give larger scaling errors than IBD-GS using selective genotyping.
The intent of this manuscript is to describe the results of a pilot study designed to evaluate the impact of a large-scale interprofessional medication error prevention workshop on student perceptions of team-based patient care in the prevention of medication errors.
Dual applications on two NGS platforms is simply a more systematic and large-scale method of error correction.
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