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Though a large trial in Linxian, China, found decreases in stomach cancer in people randomly assigned to supplements including vitamin E, selenium and beta carotene, that population suffered from chronic nutritional deficiencies, and stomach cancer was more common than in the United States.
The scientific debate could be resolved with a large trial in which patients were randomly assigned to X-rays or protons and tracked for years.
We describe the rationale behind various aspects of the design and discuss the complexities involved in undertaking such a large trial in HIV-infected patients from 180 clinical sites in 17 countries.
This provides an instructive example of the need to develop a large trial in several stages.
In another large trial in 1568 men with lower extremity arterial disease, bezafibrate reduced the severity of intermittent claudication [ 17].
Although we support the use of steroids for treating septic shock, we clearly need a large trial in this area.
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Scientists do not have a full understanding of why the vaccine failed, or why it was possibly harmful, in two large trials in the United States and South Africa.
In a study published last month in The Journal of the American Medical Association, researchers in Europe analyzed data from 68 large trials in which more than 232,000 adults were given antioxidant supplements.
TPE worth to be evaluated in large trials in ACLF' patients, with a liver transplant project, and a lesser degree of organ failure.
This is in contrast to other studies [3, 6], but in line with recent large trials in which ICU patients or cardiac surgery patients were randomized to fresh or stored blood [4, 20].
The study protocol was mostly feasible to implement, which encourages conducting large trials in comparable settings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com