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Considering the very large target population for a malaria vaccine, more data on the safety of RTS,S/AS01E will be needed before licensure and roll-out.
Therefore, we conclude that a potential gene therapeutic treatment with DKK3 might be of benefit for a large target population of breast cancer patients.
Since an increasingly large target population is becoming eligible for cancer genetic counselling/genetic testing, many primary care providers and General Practitioners are now also being expected to deliver relevant information to individuals at risk [ 12, 13].
Information on sickle cell disorders could also be incorporated into the basic education curriculum in Nigeria which is presently free in the country and have the advantage of reaching a large target population.
Quantitative representation is one of the most common types, but it entails a major problem: even by stratified random selection, it is hardly possible to create a statistically correct image of the (often large) target population in the (usually much smaller) group of participants.
A postearthquake immunization campaign using measles rubella and diphtheria tetanus toxoid vaccines to address the immediate threat of vaccine-preventable diseases encountered challenges that included difficulty reaching a large target population, time needed for completion (≈4 months), and achieving adequate coverage (31 ), problems that could also hamper a cholera vaccine campaign.
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The quantitative investigation of large target populations generally involves self-administered questionnaires, ideally completed at the same time as outcome measurement.
However, compared to postal mail surveys, email surveys, commonly allowing for larger target population, frequently have lower response rates [19 21].
Survey data remain an indispensable source of information, because only survey data can deliver certain types of information that non-survey data (e.g. data collected from people's behaviour on the internet) cannot, such as people's experiences and opinions, in a way that we can safely make inferences to the larger target population.
We decided to choose more liberal values to create a larger target population to be randomised.
However, compared to postal mail surveys, email surveys, commonly allowing for larger target population, frequently have lower response rates [ 19- 21].
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