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In the simplest case, large subtypes of cancers are driven by single gene alterations that are directly targetable, such as the Bcr-abl fusion protein of chronic myelogenous leukemia, and others where mutations in a particular pathway are common, but do not represent the single accelerator of tumor growth, such as EGFR mutations in subsets of lung cancer.
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Of particular interest is the large subtype of GBM tumors which overexpress epidermal growth factor receptor (EGFR), providing a feasible target for many kinds of nanoparticle therapies [ 20].
Leiomyosarcomas represent the largest subtype of soft tissue sarcomas.
Clear cell RCC (ccRCC) is the largest subtype of RCC and accounts for ∼70% of these tumours.
We labeled the four classes as follows: Optimal class: The largest subtype of adolescents (784, 69%) were those in a class with less than a 13% probability of being exposed to each indicator of adverse family environments.
Optimal class: The largest subtype of adolescents (784, 69%) were those in a class with less than a 13% probability of being exposed to each indicator of adverse family environments.
Future larger studies with subtypes of cerebrovascular disease are needed to further assess the association.
Pollen-specific receptor kinases (PRKs) share features allowing their identification as a family of pollen-specific receptor kinases among a much larger LRR subtype of receptor kinases in plants (Kim et al. 2002).
Ischemic stroke is the largest subtype, with an estimated incidence of > 80% of all strokes.
The follicular variant of PTC FVPTCC) represents the largest subtype and accounts for about 30% of all PTCs [ 3].
The follicular variant of PTC (FVPTC) represents the largest subtype and accounts for about 30%% of all PTCs [ 2].
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