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Of particular interest is the large subtype of GBM tumors which overexpress epidermal growth factor receptor (EGFR), providing a feasible target for many kinds of nanoparticle therapies [ 20].
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In the simplest case, large subtypes of cancers are driven by single gene alterations that are directly targetable, such as the Bcr-abl fusion protein of chronic myelogenous leukemia, and others where mutations in a particular pathway are common, but do not represent the single accelerator of tumor growth, such as EGFR mutations in subsets of lung cancer.
Leiomyosarcomas represent the largest subtype of soft tissue sarcomas.
Clear cell RCC (ccRCC) is the largest subtype of RCC and accounts for ∼70% of these tumours.
We labeled the four classes as follows: Optimal class: The largest subtype of adolescents (784, 69%) were those in a class with less than a 13% probability of being exposed to each indicator of adverse family environments.
Optimal class: The largest subtype of adolescents (784, 69%) were those in a class with less than a 13% probability of being exposed to each indicator of adverse family environments.
Pollen-specific receptor kinases (PRKs) share features allowing their identification as a family of pollen-specific receptor kinases among a much larger LRR subtype of receptor kinases in plants (Kim et al. 2002).
Ischemic stroke is the largest subtype, with an estimated incidence of > 80% of all strokes.
The follicular variant of PTC FVPTCC) represents the largest subtype and accounts for about 30% of all PTCs [ 3].
The follicular variant of PTC (FVPTC) represents the largest subtype and accounts for about 30%% of all PTCs [ 2].
Even the node connecting the subtype B and D sequences was no longer distinct because of sequences falling basal to the two lineages, which made the subtype B strains appear to be part of a larger subtype D group.
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CEO of Professional Science Editing for Scientists @ prosciediting.com