Sentence examples for large subsequent studies from inspiring English sources

Although an effect of high numbers of repeats on cancer risk in carriers was first reported by Rebbeck and colleagues [ 12], three large subsequent studies failed to replicate this result [ 13- 15].

Although early case control studies in the UK indicated a link between PCOS susceptibility and the insulin gene variable number of tandem repeats microsatellite length (Franks et al., 1999; Michelmore et al., 2001), a large subsequent study in more than 3000 women from the UK and Finland found no such association (Powell et al., 2005).

Larger subsequent studies should clarify the effect of exenatide on trends in cardiovascular markers, including weight loss and SBP, and explore the potential for lowering overall risk.

The results by demographics provided some valuable information for the sampling plan in the larger subsequent study.

Having 10 participants in each arm of this study was considered sufficient to obtain preliminary data to help with estimating power for a larger subsequent study.

However, it could serve as an a priori hypothesis to be formally tested by a larger subsequent study, ideally with pre-planned multivariate analysis to account for additional clinical and imaging parameters.

Often, initial studies focus on a narrow, homogeneous population in which effects are likely to be large, but subsequent studies occur in samples that include more individuals for whom the treatment may be less effective.

The protective effect of pregnancies against breast cancer was first described as early as 1926 (Press and Pharoah, 2010), and was confirmed through a large number of subsequent studies (Kelsey et al, 1993).

We expect to scale up this approach to larger populations in subsequent studies.

Therefore, if the trial yields a positive result, a larger subsequent multicentre study may be needed.

Subsequent studies in large cohorts, however, consistently reported that the presence and/or levels of autoantibodies such as RF and ACPA were not related to the synovial ELN [ 5, 13, 14].