Large studies with a randomized controlled design or other designs such as crossover or off-on-off-on are needed.
In small studies, or large studies with many important prognostic covariates or analytic subgroups, design-adaptive allocation is an extremely attractive method of treatment assignment.
Two recent large studies with the low-molecular-weight heparin (LMWH) enoxaparin have shown that this agent significantly reduces the risk of major ischemic events compared with unfractionated heparin.
If we can show that subjects may visit the clinic less often than every 8 weeks and not miss important laboratory-related drug toxicities, then it may be feasible to conduct large studies with simpler designs without compromising the subjects' health.
Large studies with two DPP4 inhibitors (SAVOR-TIMI 53 and EXAMINE) to which today led authorities (FDA, EMA, HAS/Ansm) and scientific societies (ADA, EASD, IDF) to conclude the absence of excess risk of cancer of the pancreas and thyroid in T2DM patients treated with incretin.
Large studies with the power to detect significant associations at genome-wide level have not yet been conducted.
In two relatively large studies with 31 [20] and 51 [21] patients, respectively, no decrease in blood flow velocity was found with TCD during migraine attacks.
Reliable clues will require large studies with thousands of possible genes, he says; individual ones can only be expected to have very small effects.
And in large studies with blood donors, his team has not found pieces of viruses that would evade antibody-based tests.
In recent decades, large studies with better methods have provided conclusive, consistent evidence that abortion is unrelated to breast cancer risk.
Large studies with well-powered validation cohorts are needed.
