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A large structural difference in the channel occurred when Lys23 was acetylated, manifested by the second transmembrane helix (residues 76 87) being perturbed due to interactions with acetylated Lys23.
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We observe large structural differences between the different systems.
These five classes show very large structural differences (Figs. 3 and S2).
Large structural differences between HF and DFT results for (C24S24)+ indicate the importance of electron correlation effects for these molecules.
Large structural differences between the nanomaterials produced in the two cases are shown: the use of DI-H2O induces a large number of pentagon heptagon defects in the nanotubes, compared to the use of LN2.
The specificity of soraphen is explained by large structural differences between the eukaryotic and prokaryotic BC in its binding site, confirmed by our studies on the effects of single-site mutations in this binding site.
Homology between the two forms is masked by large structural differences between them.
16 Thus, one would not expect large structural differences in the ion channel with flip in orientation of N-terminal domain.
In fact, there are more large structural differences between the CAST/EiJ strain and the mouse reference annotation than among all of the humans in the 1000 Genomes Project 25,000 vs. 14,000.
It is worthwhile noting that we are looking for the mutation with the largest structural difference from the wild type, while in [ 15] the ultimate goal was to look for a mutation that can lead to a bistable conformation.
However, the broad distributions of the cryocooled structures suggest much larger structural differences, which are likely due to nonspecific perturbations caused by the cryocooling process and not due to ligand binding.
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