Exact(1)
Despite the large structural and functional diversity of the mammalian antibody repertoire, conventional antibodies (i.e. heterotetramers of two light chains and two heavy chains) acting as competitive enzyme inhibitors are scarcely found in bibliography.
Similar(59)
Moreover, direct connections between the motor cortex and other brain regions show the largest structural and functional impairments in patients with ALS.
The large-scale structural and functional network connectivity changes of mTBI are still unknown.
Hadi Hosseini is a computational/cognitive neuroscientist investigating large-scale structural and functional brain networks in various neurological and psychiatric conditions using multimodal neuroimaging, graph theoretical and multivariate pattern analyses techniques.
High-throughput protein production systems have become an important issue, because protein production is one of the bottleneck steps in large-scale structural and functional analyses of proteins.
Advances in cardiovascular imaging and diagnostics have led to the easy acquisition of large quantities of structural and functional information, which cannot be handled "intuitively".
However, it also showed that even mechanically stable scaffolds do not allow regeneration of a large mass of structural and functional cartilage within a matrix architecture seeded with 2D passaged chondrocytes in combination with a cell biomimetic carrier.
Thus, alternative splicing provides a large diversity of structural and functional variation in GABAB1 receptors.
The antibodies constitute an excellent model to test the potential approaches to this problem because they constitute a homogeneous family of proteins and a large amount of structural and functional data is available.
The focused attention on LeuT has produced a large amount of structural and functional information that underscores the importance of establishing to what extent the knowledge accumulated from this bacterial homologue can explain the corresponding functional mechanisms in the mammalian NSS transporters, at the same detailed molecular level.
This is the first report for that MBP fused recombinant CCR3 (MBP-CCR3) produced in E. coli still maintains its binding activity with its endogenous ligands, which provides an efficient way to produce functional GPCR proteins at large scale for further structural and functional studies.
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