The success of the original open-label study lead to larger, more stringent double-blind, placebo-controlled, randomized clinical trials (Tables 2 and 3).
The effect of the MAF threshold on the conclusion is smaller, but for the SKAT statistic, it can be seen that higher MAF thresholds correspond to more interwindow correlation and hence to larger (less stringent) significance thresholds.
To compare the types and levels of alternative tandem splice site exons occurring in different human organ systems and cell types, and to study known sequence features involved in the recognition and distinction of neighboring splice sites, we performed large-scale, stringent alignments of cDNA sequences and ESTs to the human and mouse genomes, followed by experimental validation.
The number of measurements in the sample set defines how many standard deviations from the mean are acceptable; the larger the set the larger (and less stringent) the acceptable range.
Thanks in large part to stringent regulation, Spanish banks are rightly being applauded for the way they steered clear of toxic credit derivatives and shadowy off-balance-sheet exposures.
RO, in the form of VSEP (vibratory shear enhancing processing), has also been used in the full scale for removing selenium from stripped sour water to help a large refinery meet stringent discharge requirements.
Based on their sequence similarity, the GreenPhylDB clusters gene families at different levels from the less stringent (large clusters of relatively similar sequences at Level 1) to the most stringent (small clusters of highly similar sequence at Level 4).
As judged by the criteria of replication, GWASs have been among the most successful epidemiological study designs to date, in no small measure due to large sample sizes, stringent quality control, simplicity of experimental design, and collaborative transparency between researchers.
Despite this large variation, the stringent selection procedures used to extract orthologs make for reliable comparisons as evident by the facts that 1) the ranges of K a values are equivalent across lineages and 2) by removing the lineage with the smallest ortholog set the trend did not change.
The JTC has higher space-bandwidth product, lower carrier frequency, higher index modulation, and suitability for real-time implementation, but also displays inefficient use of illumination and a required larger transform lens, stringent spatial coherence, and small size of the joint-transform spectrum.
Identification of single molecules from a highly complex mixture such as plasma requires a combination of separation techniques to reduce complexity and a stringent large-scale screening method.
